RESCUE OF IN VITRO MODELS OF CSF1R-RELATED ADULT-ONSET LEUKODYSTROPHY BY ILUZANEBART: MECHANISMS AND THERAPEUTIC IMPLICATIONS OF TREM2 AGONISM

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism

Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related Drone Accessories adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP).CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R

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